The Collaborative Research Center SFB 578 "Development of
Biotechnological Processes by Integrating Genetic and Engineering
Methods – From Gene to Product –", aims at combining
and integrating methods available both from the basic sciences
and the fundamental engineering sciences, notably genetics and
biochemical engineering, to obtain high value-added products.
The work primarily concerns processes for the microbial production
of new heterologous proteins by recombinant production strains.
The bacteria Escherichia coli (gram-negative) and Bacillus megaterium
(gram-positive) as well as the mycelium-forming fungus Aspergillus
niger are used as host organisms. The products under study are
either pharmaceutically active (antibodies, bone morphogenetic
proteins) or serve as biocatalysts to synthesize new oligosaccharides.